Obtained results

One of the major concerns of classical anti-tumoral agent administration in the treatment of osteosarcoma is their increased toxicity on normal tissues (which induces severe adverse reactions). Therefore, the development and implementation of efficient therapeutic alternatives represents a highly interested domain in the treatment of osteosarcoma and associated infections.
This Project opened new research directions towards the development of laser-assisted applications in the medical field to obtain multifunctional surfaces. The main result of this Project was the fabrication of new multifunctional surfaces embedding chemotherapeutic nanostructures and antimicrobial therapeutic agents, capable of preventing the recurrence of bone cancer and microbial contamination, colonization and biofilm development at the bone-implant interface.
The therapeutic efficiency of the proposed materials was demonstrated by in-depth studies of the response depending on the time and dose of the drug administration, being reported high toxic effects on the tumoral cells and low effects on the normal ones, with sustained antimicrobial and antibiofilm activities. The effect of the new synthesized materials evidenced that they induce a low level of toxicity on normal cells (including the osteoinductive capacity) and a high level against tumoral cells.
The biological performances of the nanostructured coatings developed in this Project, validated on cell cultures with clinical impact, confirm their potential application in hard tissue engineering and bone implantology, including strategies to prevent and combat peri-prosthetic infections and management of anti-tumoral recurrence.